Pardis Sabeti, M.D. D.Phil.
Assistant Professor of Organismic and Evolutionary Biology
Center for Systems Biology
Phone: 617-384-5335
E-mail:
Office: Northwest
Lab, Room 469.30,
52 Oxford St. Cambridge,
MA 02138
The goals of the Sabeti lab are to study the effect of natural selection on the human genome and the genomes of other organisms and uncover the traits that have emerged to shape these species, and to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci: (1) developing analytical methods to detect and investigate natural selection in the genome of humans and other species, (2) pursuing signals of natural selection in humans to identify their underlying functional trait and the mechanism of evolution (e.g resistance to Lassa fever virus, and hair, sweat, and teeth development), and (3) examining signals of natural selection in pathogens to understand how they rapidly evolve to remain agents of human morbidity and mortality.
Recent Publications
Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr., Johns CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC. (2011) Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genetics 2011, in press.
Grossman SR, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC. (2010) A composite of multiple signals distinguishes causal variants in regions of positive selection. Science 2010, 327:883-6.
Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, et al. Genome-wide detection and characterization of positive selection in human populations. Nature 2007,449:913-918.
Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, et al. Positive natural selection in the human lineage. Science 2006,312:1614-1620.
Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 2002,419:832-837.
