OEB Seminar Series


Thursday, February 14, 2019, 3:30pm


Biological Labs Lecture Hall, Room 1080, 16 Divinity Avenue

Felicity Jones Felicity Jones
Research Group Leader
The Friedrich Miescher Laboratory of the Max Planck Society

"Molecular Mechanisms Underlying Adaptive Divergence In Sticklebacks"

Abstract: The ability of organisms to rapidly adapt to new environments is both facilitated and constrained by molecular mechanisms that are often challenging to dissect in non-model organisms. Our previous work has used the powerful parallel divergent adaptation to marine and freshwater environments in threespine stickleback to map >81 predominantly intergenic adaptive loci with kilobase resolution. This presents a unique opportunity to discover and functionally dissect molecular mechanisms influencing evolution in a naturally adapting organism. In my talk I am going to discuss two linked aspects of this research programme: defining the components of transcription regulation using functional genomics approaches like allele-specific RNAseq, ChIPseq, ATACseq, and transgenic assays, and charting variation in the recombination landscape among individuals, sexes and ecotypes using whole genome sequencing of pedigrees, linked-read sequencing and ChIPseq methods. These approaches highlight how cis-acting changes are particularly important for divergent adaptation with on-going gene flow because they are closely linked to the genes whose expression they regulate; and together with maps of recombination hot- and coldspots show how linked haplotypes facilitate adaptive divergence. Together these approaches provide key insight into how fundamental biological processes such as meiosis and gene regulation shape the adapting genome in the early stages of divergence and ecological speciation.

See also: OEB Seminars